| Nickname | Description | Category | Source | Updated |
|---|
| 007s | Methylenedioxymethamphetamine (MDMA) | Other | | |
| 100s | Lysergic acid diethylamide (LSD) | Other | | |
| 100 | A 100 size cigarette | Cigarettes/Tobacco | | |
| 11350 | cocaine, California Health and Safety Code section (usually refers to citation or arrest) | Cocaine | | |
| 11357 | marijuana, California Health and Safety Code section (usually refers to citation or arrest) | Cannabis/Marijuana | | |
| 11550 | dangerous drugs, California Health and Safety Code section (usually refers to citation or arrest) | Other | | |
| 151 | Crack Cocaine | Other | | |
| 1UP's | after the 1-up mushrooms in the Super Mario Bros. games for Nintendo. | Psychedelic mushrooms | | |
| 2-for-1 sale | A marketing scheme designed to promote and increase crack sales | Other | | |
| 24-7 | Crack Cocaine | Other | | |
| 256 | BLO on a telephone keypad | Cocaine | | |
| 25s | Lysergic acid diethylamide (LSD) | Other | | |
| 2CB | Nexus | Other | | |
| 30s | common type of marijuana, lower quality than flame and dank, but better than shwag | Cannabis/Marijuana | | |
| 3750 | Marijuana and crack rolled in a joint | Other | | |
| 4.20/420 | 4/20 is known in the U.S. as the natitonal weed smoking holiday when people smoke weed or smoke more weed then they do on a normal basis. when some pupils will use cannabis; also could be reference to American equivalent of the holiday "J-Day" which falls on the twentieth of April (4/20). | Cannabis/Marijuana | | |
| 40-bar | OxyContin pill | Other | | |
| 40 | OxyContin pill | Other | | |
| 420 | Marijuana use | Other | | |
| 420 | marijuana | Other | | |
| 420 | prison slang for cannabis. | Cannabis/Marijuana | | |
| 45 Minute Psychosis | Dimethyltryptamine | Other | | |
| 50 | A regular cigarette | Cigarettes/Tobacco | | |
| 51er | A joint or blunt filled with marijuana and a line of cocaine. | Other | | |
| 51 | Combination of crack cocaine with marijuana or tobacco | Other | | |
| 51 | marijuana joint rolled with cocaine -Detroit area | Cocaine | | |
| 57 Chevy | from the Eric Clapton song "Rock 'N' Roll Heart" | Heroin | | |
| 69s | Methylenedioxymethamphetamine (MDMA) | Other | | |
| 7 up | 7 grams (1/4 ounce) | Cocaine | | |
| 714s | Methaqualone | Other | | |
| 714 | Methaqualone | Benzodiazepines, Barbiturates and Miscellaneous Depressants | | |
| 8 ball | 3.5 grams (1/8 ounce) | Cocaine | | |
| 80 | OxyContin pill | Other | | |
| ; someone who looks and dresses dirty cause of smoking dope Skies | refers to scales used to weigh drugs | Other | | |
| A Bean | MDMA | Other | | |
| A Big One | a pound of marijuana | Cannabis/Marijuana | | |
| A Sidani | Uptown New-Jersey slang | Heroin | | |
| A bomb | if smoked in a cigarette | Heroin | | |
| A | LSD; amphetamine | Other | | |
| A-Plus | Refers to use of amphetamines among college students as a "study aid" | Amphetamines | | |
| A-Train | To use any type of amphetamine | Amphetamines | | |
| A-bomb | Marijuana cigarette with heroin or opium | Other | | |
| A-boot | Under the influence of drugs | Other | | |
| A1-Yola | slang | Cocaine | | |
| AC/DC | Codeine cough syrup | Other | | |
| AC/DC | codeine cough syrup | Other opioids | | |
| AD | PCP | Other | | |
| AIP | Heroin from Afghanistan, Iran, Pakistan | Other | | |
| AIP | heroin from Afghanistan, Iran, and Pakistan | Other | | |
| AMT | Dimethyltryptamine | Other | | |
| Abandominiums | Abandoned row houses where drugs are used | Other | | |
| Abe's cabe | $5 bill | Other | | |
| Abe | $5 worth of drugs | Other | | |
| Abolic | Veterinary steroids | Other | | |
| Abolic | veterinary steroid | Other | | |
| Aborts | absolut vodka and port, mixed together | Other | | |
| Abu-Sufian | a very potent form of hydroponics smoked by hardcore gangsters. | Cannabis/Marijuana | | |
| Acapulco gold | Marijuana from S.W. Mexico; marijuana | Other | | |
| Acapulco gold | a very potent strain of marijuana from Acapulco, Mexico. | Other | | |
| Acapulco gold | marijuana from S.W.Mexico | Other | | |
| Acapulco red | Marijuana | Other | | |
| Ace | Marijuana cigarette; PCP | Other | | |
| Ace | giving the last few pulls of a cigarette | Cigarettes/Tobacco | | |
| Ace | marijuana; PCP | Other | | |
| Acid cube | Sugar cube containing LSD | Other | | |
| Acid freak | Heavy user of LSD | Other | | |
| Acid head | LSD user | Other | | |
| Acid head | User of LSD | Other | | |
| Acid head | user of LSD, "Acid Freak" | Other | | |
| Acid tabs | slang | LSD | | |
| Acido (Spanish) | Hallucinogens; LSD | Other | | |
| Acid | slang | LSD | | |
| Acid | LSD | Other | | |
| Adam | MDMA | Other | | |
| Adam | Methylenedioxymethamphetamine (MDMA) | Other | | |
| Adam | early term used in the context of psychotherapy | Ecstasy (MDMA) | | |
| Adderall | slang | Amphetamines | | |
| Addies | Slang for Adderall | Amphetamines | | |
| Adolf | slang | Morphine | | |
| Ad | PCP; drug addict | Other | | |
| Aeon flux | Lysergic acid diethylamide (LSD) | Other | | |
| Affe | Common in Sweden | Amphetamines | | |
| Afgani indica | Marijuana | Other | | |
| Afi | short for Afghani variety of marijuana characterized by seedless buds | Cannabis/Marijuana | | |
| African black | Marijuana | Other | | |
| African bush | Marijuana | Other | | |
| African woodbine | Marijuana cigarette | Other | | |
| African | Marijuana | Other | | |
| Agonies | Withdrawal symptoms | Other | | |
| Ah-pen-yen | Opium | Other | | |
| Ahackie Mission | slang | Anabolic steroids | | |
| Aimes | Amyl nitrite | Other | | |
| Aimies | slang | Amphetamines | | |
| Aimies | Amphetamine; amyl nitrite | Other | | |
| Air blast | Inhalants | Inhalants | | |
| Airhead | Marijuana user | Other | | |
| Airhead | under the influence of marijuana | Other | | |
| Airplane | Marijuana | Other | | |
| Ak-47 | a strain known for its sticky consistency and crystal covered exterior | Cannabis/Marijuana | | |
| Al Capone | Heroin | Other | | |